Interstitial Lung Disease Catherine Chen and Adrian Shifren GENERAL PRINCIPLES Definition • Interstitial lung disease (ILD) describes a heterogeneous group of over 200 diseases affecting the pulmonary interstitium with varying degrees of involvement of the pleural space, airways, and pulmonary vasculature. Interstitial lung disease (ILD) is a heterogeneous group of disorders that are characterised by varying degrees of fibrosis and inflammation of lung parenchyma. Interstitial lung disease and adult-onset Still's disease. Dr. Sally Suliman presents "Interstitial Lung Disease" by first introducing the classification of ILDs. The scarring causes stiffness in the lungs which makes it difficult to breathe and get oxygen to the bloodstream. Patients are often hypoxemic, and pulmonary function tests typically demonstrate a restrictive pattern, with reduced diffusing capacity. Adult Still's disease and respiratory failure in a 74 year old woman. Interstitial lung disease is a general category that includes many different lung conditions. Historically, terminology and classification of interstitial lung disease (ILD) in children have mirrored those of adult disease, but this is generally not helpful. It concerns alveolar epithelium, pulmonary capillary endothelium, basement membrane, and perivascular and perilymphatic tissues. According to the characteristics of HRCT features of lung disease, the SK-DenseNet … None of the pre-existing lung disease included previous ILD. ILD early and accurate diagnosis is challenging due to heterogeneity of the disease. 2018 May 22;9(11):2054-2060. doi: 10.7150/jca.24936. eCollection 2018. Clinical classification groups ILD by its causes to help differentiate exogenous or endogenous factors. • ILD is not one disease but several diseases that do not necessarily share a common histopathological or pathophysiological basis The Lancet Respiratory Medicine , … Only six patients had lung biopsy, making classification difficult, with three cases unclassified. 1999;160:899-905. Sari I et al. INTRODUCTION "Diffuse interstitial lung disease" (ILD) is a generic term encompassing a broad range of largely unrelated conditions that share the propensity to cause breathlessness and/or cough associated with bilateral abnormal opacities of various types on conventional chest radiographs or high resolution computed tomographic (HRCT) scans (algorithm 1). Background: There is growing recognition and understanding of the entities that cause interstitial lung disease (ILD) in infants.These entities are distinct from those that cause ILD in older children and adults. J Cancer. Classification of Diffuse Parenchymal Lung Disease DPLD IIP UIP Non-UIP (IPF) Cellular NSIP Fibrotic Am J Respir Crit Care Med (2002)165:277-304 Daniil ZD, et al. Interstitial lung diseases are a group of diffuse parenchymal lung disorders associated with substantial morbidity and mortality. This paper presents an improved DenseNet called small kernel DenseNet (SK-DenseNet) to improve ILD classification performance. nonspecific interstitial pneumonia (NSIP), cryptogenic or-ganizing pneumonia (COP), acute interstitial pneumonia (AIP), respiratory bronchiololitis-associated interstitial lung disease (RB-ILD), desquamative interstitial pneumo-nia (DIP), and lymphoid interstitial pneumonia (LIP). Patients invariably present with dyspnea of varying time course and severity. All interstitial lung diseases affect the interstitium, a part of the lungs' anatomic structure. The contributions of the European Respiratory Society Task Force on Interstitial Lung Disease in Children and the North American Children's Interstitial Lung Disease Group are reviewed, and a clinicopathologic classification of paediatric diffuse lung disease is summarized. SECTION 11 Immunologic and Interstitial Diseases CHAPTER 54 Interstitial Lung Disease: A Clinical Overview and General Approach Danielle Antin-Ozerkis INTRODUCTION Commonly, interstitial lung disease (ILD) presents with dyspnea on exertion, diffuse bilateral infiltrates on chest imaging, and restriction with diffusion impairment on physiologic testing. Lung damage from ILDs is often irreversible and gets worse over time. Classification. Diseases in this group show common characteristics clinically, radiologically, pathologically and functionally. Worsening hypoxia and respiratory failure may develop with disease progression. 1993;12(3):418-21. Van Hoeyweghen RJ et al. 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